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Raw data from the CRISPR knockout screen are in Supplementary Table 2

Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining

Chemotherapy-Induced Neuropathy CAUTION Hershman et al

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Furthermore, SUN significantly reduced activity of AMPK following treatment with the AMPK activator, AICAR, as evidenced by decreased P-ACC2 protein expression and the degree of inhibition was parallel to that seen with the AMPK inhibitor, compound C [17]