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Metformin, commonly used in diabetes management, has been associated with reduced vitamin B12 absorption, potentially through effects on calcium-dependent vitamin B12-intrinsic factor absorption in the terminal ileum

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One key group includes individuals with pernicious anemia, an autoimmune condition that affects the bodys ability to absorb vitamin B12 from food

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At that concentration, 250 mcg equals 0.05 mL, or 5 units on a U-100 insulin syringe