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A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice

We frame this complexity through the concept of proteostasis resilience, defined as the ability of cells and tissues to maintain proteome stability under stress, and use it to unify disease mechanisms with therapeutic opportunity

10.1038/mp.2014.62 151 TelloneE.GaltieriA.RussoA.GiardinaB.FicarraS

Growth hormone is a natural signal the body makes

Mice were maintained in a temperature-controlled room (2122 C) on a 12 hr light/dark cycle and supplied with food and water ad libitum

Embedding DOX in the erythrocyte membrane can completely solve its solubility problem and eff ectively reduce the toxic side effects of adjuvants