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2010 Jun;13(3):579-83

The mechanism relies on targeting two enzymes essential for DNA replication and repair: DNA gyrase and topoisomerase IV (Werner et al., 2011)

Although very few studies are available, the multi-target strategy is steadily gaining traction in the field of drug discovery

In contrast to reduced CD8 + T M , the enrichment of proliferating and effector CD8 + Tc was identified in moderate and severe compared to healthy BALF cells (Fig

Moreover, serum DUSP22 levels are inversely correlated with coronary artery stenosis, Th1/Th17 populations, and serum levels of CRP, IFN-, and TNF- in CHD patients

10.1016/j.bbabio.2008.12.002 Biochim