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Comput Syst Oncol 1(3), 2021

INSILICO PREDICTION OF PMDI PERFORMANCE WITH LOWGWP PROPELLANTS HFA152A AND HFO1234ZE(E) Daniel Duke 1, Lingzhe Rao1, Nirmal Marasini2, Hui Xin Ong2, David Schmidt3, Benjamin Myatt4, Phil Cocks4 & Paul Young2 1Laboratory for Turbulence Research in Aerospace & Combustion (LTRAC), Department of Mechanical & Aerospace Engineering, Monash University, Clayton, 3800, Australia 2Respiratory Technology, Woolcock Institute of Medical Research, Glebe, Sydney, NSW 2037, Australia 3University of MassachusettsAmherst, Amherst, MA 01003, United States of America 4Kindeva Drug delivery, Charnwood Campus, 10 Bakewell Road, Loughborough, United Kingdom, LE11 5RB Summary: The transition to low greenhouse warming potential propellants for pressurised metered dose inhalers will necessarily require a redesign of the nozzle orifice to compensate for changes in physicochemical properties such as reduced vapour pressure, density, and increased saturation temperature

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