chac1 glutathione Frontiers Identification of Juglone, a 'first-in-class'
Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv Regulation of ChaC1. Oxidative and ER stress, and viral infection Download Scientific Diagram A scheme of the mechanism of CHAC1 degradation of glutathione enhancing Download Scientific Diagram Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione degrading enzyme CHAC1 ScienceDirect
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