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Endogenous gene expression can also be reduced by inactivating or knocking out the gene and/or its promoter using targeted homologous recombination

PLoS Negl Trop Dis 12:e0006779

Umare MD, Khedekar PB, Chikhale RV

P.RoutledgeP

Immunol., 197, 28282837 26

The Link Between Paracetamol and Glutathione Depletion Mechanism of Action : When paracetamol is metabolized, it produces N-acetyl-p-benzoquinone imine (NAPQI), a toxic compound