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Once internalized into tumor cells through CD44 receptor-mediated active targeting, the HA shell of PTFTH would be preliminarily disassembled by hyaluronidase (HAase) to expose the Fe-TA metal-phenolic networks (MPNs), which would further degrade in response to an acidic lysosomal environment, leading to HAase/pH dual-responsive release of Fe 3+ and PFC/TRIM37

Zapater P, Lasso de la Vega MC, Horga JF, Such J, Frances R, Esteban A, Palazon JM, Carnicer F, Pascual S, PerezMateo M

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Indeed, as mentioned previously, in humans, the organ responsible for storage is the liver and partially the blood, although the kidney plays a crucial role in the reabsorption of TC [48,60]

Worksheet S-3 Part I, column 8, line 30 (total all patients' employee discount days)

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