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LOX Members and Metabolites in Atherosclerosis Since atherosclerosis is predominantly characterized by subintimal lipid accumulation and inflammation, and LOXs can promote LDL (low-density lipoprotein) oxidation and the inflammatory response, LOX subfamily factors and metabolites are intimately associated with atherosclerosis but with unclear conclusions

Subsequently, the restoration of blood flow triggers an outburst of reactive oxygen species, calcium overload, and an inflammatory cascade reaction

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