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The major conformational dynamics of AMY 1 R-Gs and AMY 2 R-Gs bound to individual peptide agonists were primarily related to motions of the combined RAMP:CTR ECD relative to the TM core, and this was also true for previously determined AMY 3 R-Gs complexes with rAmy (Fig

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Early work characterized stability in human gastric juice and resistance to enzymatic degradation under acidic conditions (Sikiric et al., 2011)

The combo injection also resulted in a greater reduction in HbA1c versus the individual drugs