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The elevated oxalate levels increase inflammation and fibrosis.[ref] Related article : Fatty liver disease NLRP3 inflammasome activation: The NLRP3 inflammasome is activated by increased ROS and calcium oxalate crystals

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80,83 Recent studies have shown that metformin, by activating the AMPKSIRT2 axis, restores the expression of key glycolytic enzymes suppressed by insulin, thereby enhancing glycolytic flux in ovarian granulosa cells