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Alzhaimers disease Alzhaimers disease (AD) is a chronic neurodegenerative disease characterized by the pathological accumulation of -amyloid peptides and neurofibrillary tangles into the brain, that usually starts slowly and gets worse over time up to dementia

It is found in most body cells, with the highest concentration in the liver

For instance, ascorbate level reduces for nearly 50% in leukocytes in individuals at age 85 and above compared to those at age 60 (Attwood et al., 1978)