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In an experiment using hydrogen peroxide to induce oxidative stress in granulosa cells, EVs derived from granulosa cells contain Nrf2mRNA, an mRNA that can activate antioxidant signaling pathways in other cells, particularly oocytes, thus resisting the oxidative stress environment (Saeed-Zidane et al., 2017)

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doi: 10.1016/j.yexcr.2021.112800 64 ZhuZDuanPSongHZhouRChenT

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Abstract Cancer treatment is hampered by resistance to conventional therapeutic strategies, including chemotherapy, immunotherapy, and targeted therapy

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10.1016/j.ejca.2005.09.011 29 DuL.WangH.HeL.ZhangJ.NiB.WangX.et al (2008)

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NAPDH Oxidases Provide One Source of Death-Inducing Ros in Erastin-Treated Cells Blocking system x c inhibits cysteine-dependent glutathione (GSH) synthesis and inhibits the trans-plasma membrane cysteine redox shuttle (Banjac et al., 2008

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P.EarlesA.JohnsonR

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