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These effects are partly mediated through the upregulation of pro-apoptotic Bax and the downregulation of anti-apoptotic Bcl-2 proteins, consistent with the activation of the intrinsic apoptosis pathway

Concurrently, PdH nanoparticles activated intracellular antioxidant defenses through heme oxygenase-1 (HO-1) induction and the Nrf2-antioxidant response element (ARE) pathway

The induction of Sestrin2 by YAP, in turn, affects cell survival by inhibiting the mTORC1 pathway [229]

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B12 also plays a vital role in producing healthy red blood cells that carry oxygen, preventing conditions like megaloblastic anaemia, and is involved in DNA synthesis