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Insulin-like growth factor-1, as discussed earlier, has implications on lipid and glucose metabolism [87, 88], and its exogenous administration enhances insulin sensitivity in healthy adults [139, 140] as well as those with T2D [155]

Osteoarthritis is the commonest form of arthritis and is a common cause of hip pain, especially amongst older people

Mary Armonios of the Johns Hopkins Kimmel Cancer Center, maintaining normal telomere length is inversely correlated with immune system abnormalities, and a 2013 review notes that melatonin modulates immune responses by helping to proliferate immunocompetent cells and secrete immune mediators.18 19 Tumor suppression The telomere-lengthening, along with the attendant increase in immune function, may help ward off cancer as well

doi: 10.1038/s41574-019-0273-8 5 McDonoughCAChoykeSBartonKEMassSStarlingAPAdgateJLet al