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Biotechnol Adv

Cordoba J, Alonso J, Rovira A, Jacas C, Sanpedro F, Castells L, Vargas V, et al

In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis

These variants likely helped Inuit avoid blood lipid overshoot and maintain cardiovascular health despite their high-fat diet (51)

This result is consistent with the findings of Haghighatdoost et al

Availability of data and materials The datasets used and analyzed during the current study are available from the corresponding author on reasonable request