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Feigin VL, et al

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However, other (TBK1-independent) activities of mutant p53 may also affect the tumor microenvironment

These side effects may affect quality of life and treatment adherence in adolescent patients (Meyers et al., 2021)

While PSP diagnosis typically relies on clinical features, neuroimaging and response to levodopa can provide further diagnostic support

This process is thought to be due to accumulation of mutations in cancer-related genes, including oncogenes, tumor-suppressor genes, and DNA mismatch repair (MMR) genes