This syndrome is characterized by accelerated aging, with affected individuals displaying features such as hair loss, joint abnormalities and cardiovascular disease, with a reduced lifespan
however, in specific genetic contexts, its abnormal splicing or functional inactivation may lead to insufficient intracellular iron accumulation, thereby limiting Fenton reaction efficiency and attenuating radiotherapy-induced lipid peroxidative damage (196).Conversely, overexpression of ACSL3, a member of the long-chain fatty acid-CoA ligase family, enhances the activation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), promoting the synthesis of oxidation-sensitive phospholipids like AA-PE and significantly increasing membrane susceptibility to radiotherapy-induced lipid peroxidation (197)
Patients should not attempt to use this medicine on their own
Roxas VP, Lodhi SA, Garrett DK, Mahan JR, Allen RD (2000) Stress tolerance in transgenic tobacco seedlings that overexpress glutathione S-transferase/glutathione peroxidase
Response of human fibroblasts to implant surface coated with titanium dioxide photocatalytic films
10.1007/s12035-012-8318-1 Mol