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This high prevalence underscores the significance of macrocytic erythrocytes as a common aspect of the clinical phenotype in individuals with LND and its variants (12)

doi: 10.1128/mBio.00436-16 96 ZhouWYangJSarenGZhaoHCaoKFuSet al

Mean (standard deviation) apixaban unbound fraction was 6.8% (1.4), 7.9% (1.8), and 7.1% (1.3) in subjects with mild or moderate hepatic impairment and in healthy subjects