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Without Ran-GTP, cargos can enter and explore the entire NPC, but they are roughly 100 times more likely to exit the NPC on the cytoplasmic side, thus failing to reach the nucleus 22

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PMID: 9606175, PMCID: PMC2230367, DOI: 10.1007/bf03401919

According to the TCM pattern types, AF was classified into vigorous fire due to yin deficiency, qi deficiency and blood stasis, deficiency of both qi and yin, and phlegm-heat harassing the heart, and so on

Common pathways involving genes associated with protein degradation are frequent in neurodegenerative disorders