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Abbreviations ACE: serum angiotensin converting enzyme AFB: acid-fast bacteria AMA: anti-mitochondrial antibody ERCP: endoscopic retrograde cholangiopancreatography MRCP: magnetic resonance cholangiopancreatography MRI: magnetic resonance imaging p-ANCA: peripheral anti-neutrophil cytoplasmic antibody PBC: primary biliary cirrhosis PSC: primary sclerosing cholangitis Declarations Acknowledgement The support of the Herman Lopata Chair in Hepatitis Research (to GYW) is gratefully acknowledged

Confidence assessment of the simcyp time-based approach and a static mathematical model in predicting clinical drug-drug interactions for mechanism-based CYP3A inhibitors

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In particular sub-embodiments, the method comprises administering 10 mg/kg of durvalumab to the patient about every two weeks

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