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SKU: 14289376686
Price: 25.20 USD
Availability: InStock
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In addition to triggering the intrinsic apoptotic pathway, platinum can induce apoptosis through the extrinsic pathway via activation of FAS/FASLG or the DR/caspase-8/caspase-3 pathway [4]

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Moreover, unlike with nutlin-3 (Fig 1C) (Tarangelo et al, 2018), MPA and Pyr pretreatment protected both p53 KO and p21 KO cells from erastin2-induced cell death, consistent with RNR acting downstream of the p53/p21 axis

10.1161/CIRCULATIONAHA.117.031841 56

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