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Conclusion and prospects According to the World Obesity Atlas 2024, obesity prevalence among Chinese adults and children continues to rise, positioning obesity as a critical global health challenge across all age groups

It is likely that more than one gliotransmitter coexists within the same astrocyte, providing a new degree of complexity to astrocyte modulatory activity

Peer review Peer review information Nature Reviews Neurology thanks Hlio Teive, Ludger Schls and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Gut dysbiosis can disrupt the balance of gut microbes, leading to the production of metabolites and inflammatory molecules

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