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Further studies using humanized APOE Knock-in mice showed that BBB breakdown is mediated by apoE4 through activation of a proinflammatory cyclophilin A-matrix metalloproteinase-9 pathway in pericytes that leads to neuronal uptake of multiple blood-derived neurotoxic proteins [121]

doi: 10.1016/j.ijbiomac.2022.12.292, 10

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Patients often experience more stable energy, improved digestion, better sleep, reduced inflammation, and enhanced overall metabolic health

The crosstalk between senescent and bystander cells may occur via ROS release, extracellular vesicles secretion and/or formation of bridges allowing direct cargo transfer [reviewed in 40 ]

doi: 10.1002/hep.32130