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Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )

Despite significant advances in HCC treatment in recent decades, such as hepatic resection, liver transplantation, transarterial chemoembolization (TACE), and radiofrequency ablation, the clinical outcomes of patients remain unsatisfactory

Nat Cell Biol 1: 130135 Ellgaard L, Ruddock LW (2005) The human protein disulphide isomerase family: substrate interactions and functional properties

Future perspectives of NADs development Although many NADs have shown promising preclinical results, the number of NADs approved by the FDA for clinical use remains limited

JAAD Case Rep 6(1):5153

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