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IGFBP-2 actions are linked to insulin, although only in cases of hyperinsulinemia [173] where it seems to play a role on adipocyte autocrine control [174]

doi: 10.1093/jleuko/qiaf098

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Here we show that treatment of mice with a non-cytotoxic heavy-chain antibody that selectively inhibits CD38 ectoenzyme resulted in NAD + boosting that was associated with significant protection from fibrosis in multiple organs