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Considered as primary mechanosensors on ECs, signaling through both integrins and cell-cell adhesion molecules can lead to increases in expression of mechanotransductive factors including ERK, Src, and PI3K/Akt, among others (231235)

They examine its role in tissue protection, angiogenesis, microvascular stability, and inflammatory signaling

Wang J, Islam F, Li L, Long M, Yang C, Jin X, Ali B, Mao B, Zhou W (2017) Complementary RNA-sequencing based transcriptomics and iTRAQ proteomics reveal the mechanism of the alleviation of quinclorac stress by salicylic acid in Oryza sativa ssp

For example, a man with low progressive motility may increase the dose slowly over 8 to 12 weeks while repeating semen analysis at 3-month intervals

Mutat Res 674(12):322 Frand AR, Kaiser CA (1998) The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum