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Wang HH, Fan SQ, Zhan YT, Peng SP, Wang WY

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10.1016/j.jcis.2017.11.064 8 CaoX.WangN

Interestingly, the mutation of ATP4Ap.R703C leads to gastric acid deficiency, and the disturbance of pH balance can directly affect the physiological function of the mitochondrial respiratory chain, causing ROS signaling to be activated and triggering caspase-3-mediated apoptosis in the host cells (Bentez et al., 2020)

doi: 10.1155/2016/2412958 146 CiminiAD'AngeloBDasSGentileRBenedettiESinghVet al

For example, in a phase I/Ib trial, carboplatin was given before olaparib to patients with ovarian, breast, and uterine cancer [84]