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doi: 10.3389/fimmu.2022.986847 Received 05 July 2022 Accepted 08 September 2022 Published 23 September 2022 Volume 13 - 2022 Edited by Keiji Hirota, Kyoto University, Japan Reviewed by Michihito Kono, Hokkaido University, Japan

To combine data across different replicates, we performed fixed-effect and random-effect meta-analyses for each parameter in the best model ( Supplemental Table S13)

Nevertheless, the genetic mechanisms underlying the disease have not been extensively investigated 25

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For immunofluorescence staining of pancreas, the slides were deparaffinized and subjected to antigen retrieval, then permeabilized, blocked, and incubated with various antibodies, including anti-Glucagon (ab92517, Abcam), anti-Insulin (ab181547, Abcam), anti-Chac2 (16304-1-AP, Proteintech), and anti-MPO (AF3667, R&D systems)

Under zinc-deficient conditions, mutant SOD1 can generate highly active hydroxyl radicals and peroxynitrite via abnormal copper chemistry, further exacerbating neuronal oxidative damage and protein nitration (120)