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Sitagliptin, a selective inhibitor of dipeptidyl peptidase 4 used to treat type 2 diabetes, has been shown to suppress ROS-induced tissue damage by promoting Nrf2 translocation to the nucleus [332]

Elevated levels of oxidative damage markers, such as 8-OHdG and protein carbonyls, have been detected in ALS patients

The peptide has also demonstrated interactions with the dopaminergic and serotonergic systems, with studies showing that BPC-157 can modulate the effects of dopamine-related agents in animal models and counteract some behavioural and neurochemical consequences of both dopamine agonists and antagonists (Sikiric et al., 2010)

Weight loss of just 5-10% can measurably reduce psoriasis severity in many patients, suggesting that metabolic intervention is a legitimate therapeutic target alongside topical and systemic treatments

(i) Non-proliferative astrogliosis

Such investigations hold great promise for unraveling novel therapeutic strategies aimed at harnessing the power of glutamine metabolism to combat cancer