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Cellular Stress Resistance In preclinical models, MOTS-c has also been shown to help cells tolerate metabolic and oxidative stress, which is part of the basis for interest in its potential role in aging and age-related disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 255.Cao Y, et al

whereas more hydrophobicity of the compound could improve the brain permeability

indicated that the process of cuproptosis is accompanied by robust activation of the Wnt/-catenin pathway

This triggers a hydrophobic-to-hydrophilic transition in the ROS-responsive poly(lactic-co-glycolic acid) (PBT-co-EGDM) component of a ROS-responsive magnesium-containing microsphere (Mg@PLPE MS) shell, disrupting its integrity