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In some cases, doses are adjusted after 4 to 6 weeks based on lab results (especially IGF-1 levels, a marker of GH activity) and how the patient is feeling

It may also potentially suppress the impact of Somatostatin

In the long term, by stimulating GHRH neurons, GHS sustains its receptors by direct effect and also due to association with dopamine receptors to form GHSR1a:DRD2 heteromers 18

Increasing Bone Mass: Research in female rats has indicated that ipamorelin administration can increase bone mineral content, suggesting the development of stronger and denser bones [17]

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Doseresponse & potency: GH output rose with dose up to a saturating point near ~1 mcg/kg IV (ED50 ~0.48 mcg/kg), above which more peptide added little GH [2] [5]