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Option (Evidence Strength: Grades B, B, C, and B) Amitriptyline (Evidence Strength: Grade B ) One randomized controlled trial reported efficacy of oral amitriptyline (25 mg daily titrated over several weeks to 100 mg daily if tolerated) to be superior to placebo (63% of treatment group clinically significantly improved compared to 4% of placebo group) at four months

Therefore, results regarding oxidative stress parameters should be interpreted with caution, and future studies with larger sample sizes or complementary assays are warranted to confirm and expand these findings