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Different tissues rely on oxidative phosphorylation for energy production to varying degrees

Construction of Plasmonic Nano-Biosensor-Based Devices for Point-of-Care Testing

On the one hand, the hypoxia and cytokine storm in the inflammatory microenvironment, by activating transcription factors such as HIF-1 and NF-B, force immune cells to transform into a glycolysis-dependent phenotype ( At the same time, lactate inhibits the mTOR signaling and glucose uptake of CD8 + T cells, weakening their cytotoxic function ( The discovery of lactylation has unveiled a novel regulatory mechanism of lactate at the epigenetic level

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39: 2703 McCaffrey RP, Halsted CH, Wahab MFA, et al