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Serious vitamin B12 deficiency can cause cancer , nerve damage or anemia

The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action

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In summary: Direct neuronal Zn toxicity is unlikely to occur under physiologic conditions with routine Zn supplementation but could be encountered under conditions of cerebral ischemia, stroke, or seizures

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Neurosci Biobehav Rev 21:15166, PMID: 9062938 Stewart VC, Stone R, Gegg ME, Sharpe MA, Hurst RD, Clark JB, Heales SJ (2002) Preservation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase