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Added to this is a theoretical tumor-growth concern, reflected in the labeled warnings of approved GHRH analogs such as tesamorelin, since IGF-1 represents a growth signal for existing cell populations

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Astrocytes, in particular, contribute to the brain reserve through life-long neurogenesis 114,115 as well as through initiating and regulating synaptogenesis, synaptic maturation and synaptic extinction 52,116,117

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In this review, we attempted to provide a holistic overview of novel ODDS reported in the past five years