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If you're deficient, you end up with a series of symptoms, including fatigue, inflamed gums, spots on the skin, joint pain, poor healing, depression, and anemia

A missense mutation (G2019S) within LRRK2 modifies -synuclein pathology in a mouse PD model and increases kinase GTPase activity to inhibit autophagy and augment the pro-inflammatory response in mouse models of colitis (Takagawa et al., 2018

Ahmad AA, Gassmann M, Ogunshola OO (2009) Maintaining blood-brain barrier integrity: pericytes perform better than astrocytes during prolonged oxygen deprivation

OCA6 ALBINISM, OCULOCUTANEOUS, TYPE VII

They are already reshaping how the world thinks about obesity and metabolic health

Based on overall rates of missense variation [71, 72], we might expect every individual to carry roughly 510 missense alleles in these enzymes on average