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However, when Caspase 8 is inactivated, RIPK1 and RIPK3 mutually activate their phosphorylation and subsequently activate downstream MLKL, triggering necroptosis [155, 156, 158, 163, 164]

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Bae H, Hong KY, Lee CK, Jang C, Lee SJ, Choe K, Offermanns S, He Y, Lee HJ, Koh GY (2020) Angiopoietin-2-integrin alpha5beta1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

10.1007/s11064-013-1157-2 31 HanrahanJ