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Thus, frank and prolonged iron deficiency can favor the onset of hypothyroidism, while hypothyroidism is often associated with autoimmune gastritis or coeliac disease, negatively affecting iron absorption [16, 55]

Mechanistically, iron overload in FBXL5-deficient cells increases IL-6 production by facilitating the recruitment of nuclear factor-B to the Il-6 promoter

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The mechanisms of melatonin synthesis in the rat pineal gland has been known to be related with AANAT activation by regulating pCREB [94, 95], and by activating NF-B [96]

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