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3 Pharmacology of statins Statins are cholesterol-lowering drugs that inhibit de novo hepatic cholesterol biosynthesis through suppression of a rate-limiting hydroxyl-methyl-glutaryl Coenzyme A (HMG-CoA) reductase (Al-Kuraishy et al., Figure 2 shows the mechanisms of statins

2.7 Observational clinical study Fifty subjects were recruited at Ospedali Riuniti Villa SofiaCervello

At therapeutic doses, about 40-50% of the drug undergoes hepatic - or -oxidation into active metabolites

Dieser untersttzt die Bildung von Gefablagerungen und erhht dadurch das Risiko fr Herz-Kreislauf-Erkrankungen

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