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Optimization of the synthetic routes resulted in substantial improvement in the yields, as DYn-1 was synthesized in 2 steps (85% overall yield) and DYn-2 was synthesized in one step (96% yield)

The Bcl-2 family proteins regulate apoptosis by altering mitochondrial membrane permeabilization which leads to the release of apoptogenic factors such as cytochrome c , procaspases, and apoptosis inducing factor (AIF)

Lahm HW, Stein S

Absolute quantification of pyroglutamic acid Targeted quantification of PGA by LC-MS was performed with a specific protocol and performed according to [53,54,55] at the Swedish Metabolomics Center in Ume, Sweden