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In addition, continuous treatment of TQ (20 mg/kg/day, intraperitoneally, for 42 days) ameliorated D-Gal/AlCl 3 -induced cognitive deficit by protecting against oxidative stress, enhancing cholinergic function and increasing brain-derived neurotrophic factor (BDNF) and Bcl-2 levels [55]

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However, this increase provides a mechanism to deliver deupleted water to the mitochondria, which may be a beneficial aspect to compensate for insufficient synthesis of metabolic water by the ATPase pumps, due to deuterium overload

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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism