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LOF, loss-of-function h , Linkage analysis

Iron dysregulation becomes more evident, with NCOA4-driven ferritinophagy exacerbating oxidative injury and inflammatory cytokines (such as TNF- and IL-1) suppressing SLC7A11/GPX4 expression, further priming ferroptosis (14)

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In the United States , IGF-1 is a controlled substance and is banned by most professional sporting bodies, including the World Anti-Doping Agency (WADA) , where it appears on the Prohibited List under peptide hormones and growth factors