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(541) indicated that polyphenol consumption may decrease obesity risk in elderly adults with elevated cardiovascular risk

Acknowledgments GU thanks Fundao para a Cincia e a Tecnologia (FCT, Portugal) for PhD grant (SFR/BD/146358/2019)

Its antioxidant profile makes it an ingredient of interest for dietary supplement formulations

Among the molecular mechanisms proposed, glutamate excitotoxicity, dysregulation of transcription, altered RNA metabolism, defective axonal transport, protein misfolding and aggregation, endoplasmic reticulum stress, disrupted protein trafficking, proteasome impairment, inflammation, activation of cell death signals, mitochondrial dysfunction, and oxidative stress are the most discussed[2, 2932]

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Existing research have not compared nutritional "looting" with tumour evolution.Our study constructed risk models to predict the "fate" of tumors and identified crucial molecules that could modify the HCC competitive advantage of "looting" nutrients