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Indeed, chronic ROS can cause protein oxidation of methionine and cysteine residues 112,113 , which in the absence of GSH becomes permanent and might decrease irreversibly CI and CII functionality

Additionally, a recent research study investigates how 4-Octyl itaconate (OI), a form of itaconate functioning as a KEAP1 inhibitor, affects DSS-induced UC in mice (264)

Data availability Nucleotide sequences of codon-optimized genes can be found in Supplementary Table 6

2007;293:F994F1006

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Increasing glutathione levels helps to repair and clear the complexion