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Kellgren-Lawrence grade II: n = 28, grade III: n = 34

Current evidence is limited to this single preclinical study

Intrinsic factor enables the body to absorb vitamin B12

Future Directions While the role of the colonic mucosal barrier and microbial dysbiosis is increasingly recognised as pivotal in the development of colorectal carcinogenesis, there is only limited information on the use of biomarkers of colonic barrier status in association with CRC initiation and progression (as discussed in this review)

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