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Metallomics 2022;14:mfac034

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However, GSH depletion is a most characteristic finding when red blood cells are subjected to oxidative challenge, and in one careful study it has been demonstrated that during an attack of favism, the first measurable biochemical change is a decrease in NADPH, followed by a decrease in GSH, in keeping with stages 1 and 2 described earlier

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Due to the metabolic cycle and chemical activity of GSH reacting with other compounds, the activity of many compounds in each subsystem metabolic pathways and the level of gene transcription will ultimately determine the activity of GSH and the antioxidant capacity of plants