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Key takeaways: Some of the most notable cyclobenzaprine interactions include alcohol, drugs that increase serotonin levels, MAO inhibitors, CNS depressants, and drugs that lower the seizure threshold

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On the other hand aesculin demonstrated minimal cytotoxicity in vivo and in RAW264.7 macrophages, significantly alleviated DSS-induced colitis symptoms, and reduced inflammatory factors such as iNOS, IL-1, and TNF- in both peritoneal macrophages and colonic tissues [563]

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The cells were then detected using a flow cytometer (Cytomics FC 500, BECKMAN, Brea, CA, USA)