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185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis

& Christen, Y.) 3340 (Springer, 2016)

However, this average hydrodynamic size indicates a colloidal stability appropriate for biomedical applications, corroborated by the PDI value (inset) that evidences a low-moderate dispersion