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Good candidates for B12 injection therapy include: People with Pernicious Anemia : This autoimmune condition affects the stomach's ability to produce intrinsic factor, a protein necessary for Vitamin B12 absorption

Consequently, ANOSIM testing was also performed, which showed that clustering by treatment group was significant in each of the diversity measures (unweighted UniFrac: R value = 0.369, p = 0.0010

The 2026 Sports Medicine and JAAOS Global Research and Reviews papers (PMID 41966639, PMID 41490200) place multiple compounds including this one into the wider research context of unapproved compounds under active investigation, with attention to both the mechanism findings and the regulatory framing that researchers consulting these reviews should weigh equally

Gut microbial dysbiosis in the irritable bowel syndrome: A systematic review and meta-analysis of case-control studies